Figure 4 | Scientific Reports

Figure 4

From: CD97 is associated with mitogenic pathway activation, metabolic reprogramming, and immune microenvironment changes in glioblastoma

Figure 4

CD97 alters the GBM immune microenvironment. Compared to CD97lo GBMs, CD97hi GBM tumors exhibited significantly greater proportion of (A) nonpolarized M0 macrophages, (B) regulatory T cells, and (C) resting NK cells. In contrast, compared to CD97hi GBM tumors, CD97lo GBM tumors had higher proportions of (D) monocytes. (E) THP-1 monocytes co-cultures with wild type U251 GBM cells had significantly higher macrophage differentiation compared to those co-cultured with U251 CD97-knockdown cells (P < 0.001). *P < 0.05; **P < 0.01; ***P < 0.001.

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