Table 1 Overview of the included compounds with respectively the applied solvent and the four concentrations.

From: A large scale mass spectrometry-based histone screening for assessing epigenetic developmental toxicity

Compound (unit)

Solvent (%) in E8

Concentration

1

2

3

4

PenG (µM)54,55,56

H2O (2%)

5

50

500

5000

VPA (mM)55,56,57,58,59,60,61,62

H2O (0.01%)

0.04

0.2

1

5

ATRA (nM)55,56,59,62,63,64

DMSO (0.01%)

0.2

2

20

200

MTX (µM)56,62,65,66

DMSO (0.12%)

0.1

1

10

100

TSA (nM)60,61

DMSO (0.01%)

0.1

1

10

100

BIX (nM)37,57

H2O (0.4%)

0.01

0.1

1

10

DZNep (µM)67,68

H2O (0.4%)

0.01

0.1

1

10

Ethanol (mM)51,69

Already a solution

0.1

1

10

100

Caffeine (µM)52,53,54,56

H2O (1%)

1

10

100

500

Nicotine (µM)49,50,70

H2O (0.4%)

0.002

0.02

0.2

2