Table 2 Gag P7(NC)-P6 mutations according to HIV-1 viral subtypes.
From: Detection of Gag C-terminal mutations among HIV-1 non-B subtypes in a subset of Cameroonian patients
Class | Mutations | Overall n (%) | Subtypes n (%) | ||||
|---|---|---|---|---|---|---|---|
CRF02_AG (n = 87) | A1 (n = 22) | G (n = 12) | Others (n = 22) | p-valueb | |||
I | L449F | 8 (5.59) | 3 (3.44) | 1 (4.54) | 1 (8.33) | 3 (13.63) | 0.305 |
D480N | 8 (5.59) | 3 (3.44) | 2 (9.09) | 0 (0.00) | 3 (13.63) | 0.450 | |
L483Q | 16 (11.18) | 0 (0.00) | 11 (50.00) | 0 (0.00) | 5 (22.72) | < 0.001 | |
Y484P | 10 (6.99) | 0 (0.00) | 6 (27.27) | 0 (0.00) | 4 (18.18) | < 0.001 | |
T487V | 14 (9.79) | 0 (0.00) | 11 (50.00) | 0 (0.00) | 3 (13.63) | < 0.001 | |
II | S462L | 8 (5.59) | 4 (4.59) | 3 (13.63) | 0 (0.00) | 1 (4.54) | 0.273 |
I479G | 22 (15.38) | 18 (20.68) | 3 (13.63) | 1 (8.33) | 0(0.00) | 0.161 | |
I479K | 54 (37.76) | 25 (28.73) | 7 (31.81) | 4 (33.33) | 18(81.81) | < 0.001 | |
D480E | 36 (25.17) | 16 (18.39) | 1 (4.54) | 9 (75.00) | 10(45.45) | < 0.001 | |
III | P453L | 22 (15.38) | 10 (11.49) | 6 (27.27) | 5 (41.66) | 1 (4.54) | 0.190 |
E460A | 142 (99.30) | 86 (98.85) | 22 (100.00) | 12 (100.00) | 22 (100.00) | 1.000 | |
R464G | 138 (96.50) | 87 (100.00) | 18 (81.81) | 11 (91.66) | 22 (100.00) | 0.403 | |
S465F | 24 (16.78) | 0 (0.00) | 0 (0.00) | 8 (66.66) | 16 (72.72) | < 0.001 | |
V467E | 135 (94.40) | 87 (94.25) | 17 (77.27) | 12 (66.66) | 19 (86.36) | 0.576 | |
Q474P | 99 (69.23) | 57 (65.51) | 16 (72.72) | 4 (33.33) | 22 (100.00) | 0.320 | |
I479R | 63 (44.05) | 39 (44.82) | 10 (45.45) | 5 (41.66) | 9 (40.90) | 0.162 | |
E482G | 74 (51.74) | 68 (78.16) | 2 (9.09) | 2 (16.66) | 2 (9.09) | < 0.001 | |
T487A | 52 (36.36) | 36 (41.37) | 3 (13.63) | 5 (41.66) | 8 (36.36) | 0.139 | |
