Table 1 Univariable and multivariable analyses of the TCGA training and test datasets.
From: Development and validation of a hypoxia-associated signature for lung adenocarcinoma
Univariable | Multivariable | |||
|---|---|---|---|---|
HR [95% CI] | p | HR [95% CI] | p | |
TCGA LUAD training (n = 252) | ||||
Hypoxia | 2.12 [1.34–3.37] | 0.0011 | 2.09 [1.24–3.53] | 0.0059 |
Stage (III&IV vs I&II) | 2.22 [1.40–3.50] | 0.0005 | 1.93 [1.14–3.28] | 0.015 |
Male | 1.03 [0.68–1.57] | 0.90 | ||
Age (continuous) | 1.02 [1.00–1.04] | 0.10 | ||
Smoker (never) | 1.02 [0.55–1.89] | 1.00 | ||
Surgical margin (R1&R2) | 3.91 [1.84–8.29] | 0.0001 | 2.64 [1.20–5.84] | 0.016 |
TCGA LUAD test (n = 250) | ||||
Hypoxia | 2.13 [1.32–3.45] | 0.0016 | 1.49 [0.88–2.54] | 0.14 |
Stage (III&IV vs I&II) | 3.25 [2.08–5.09] | < 0.0001 | 3.04 [1.81–5.09] | < 0.0001 |
Male | 1.12 [0.73–1.72] | 0.60 | ||
Age (continuous) | 0.99 [0.97–1.01] | 0.40 | ||
Smoker (never) | 1.09 [0.64–1.85] | 0.80 | ||
Surgical margin (R1&R2) | 3.80 [1.51–9.57] | 0.002 | 2.69 [1.05–6.88] | 0.038 |
