Figure 2
From: Orthogonal proteomics methods to unravel the HOTAIR interactome
Identification of HOTAIR-interacting proteins by RNA-BioID. (A) Schematic overview of RNA-BioID. (B) Volcano plot showing the potential protein interactors of HOTAIR by RNA-BioID (FDR 0.05; s0 0.1). MRPLs are highlighted in blue, PRC2 complex members are highlighted in red, LSD1-CoREST members are highlighted in green. InterPro domains overrepresented in the data set (C). GO analysis showing Molecular Function (D), Cellular Component (E), and Biological Process (F). GO was performed with David 6.8., the four most significant terms are shown. The vertical dashed line represents the 0.05 cutoff used for the adjusted p-value. Number of significant proteins identified and the size of each annotation is shown next to each histogram. MCP MS2 coat protein, RBP RNA-binding domain, LFQ label free quantification.
