Scientific Reports

Table 1 Optimization of the reaction conditions for the Hantzsch condensation of para-Chlorobenzaldehyde, dimedone, ethyl acetoacetate, and ammonium acetate as the model reaction for the synthesis of polyhydroquinolines.

From: Microporous hierarchically Zn-MOF as an efficient catalyst for the Hantzsch synthesis of polyhydroquinolines


Entry	Catalyst	Amount Catalyst (mg)	Solvent	Temperature (°C)	Time (min)	Yield (%)^a,b
1	–	–	PEG-400	80	85	30
2	4,6-Diamino-2-pyrimidinethiol	10	PEG-400	80	85	41
3	Zn(NO₃)₂.6H₂O	10	PEG-400	80	85	30
4	Zn-MOF	5	PEG-400	80	85	75
5	Zn-MOF	6	PEG-400	80	85	79
6	Zn-MOF	10	PEG-400	80	85	96
7	Zn-MOF	12	PEG-400	80	85	92
8	Zn-MOF	10	EtOH	80	195	83
9	Zn-MOF	10	H₂O	80	120	N.R
10	Zn-MOF	10	DMF	80	210	60
11	Zn-MOF	10	DMSO	80	95	70
12	Zn-MOF	10	PEG-400	25	120	N.R
13	Zn-MOF	10	PEG-400	60	85	21
14	Zn-MOF	10	PEG-400	100	85	44

^aIsolated yield.
^bReaction conditions: 4-Chlorobenzaldehyde (1 mmol), dimedone (1 mmol), ethyl acetoacetate (1 mmol), ammonium acetate (1.2 mmol), catalyst (mg) and solvent (2 mL).

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