Figure 1 | Scientific Reports

Figure 1

From: H84T BanLec has broad spectrum antiviral activity against human herpesviruses in cells, skin, and mice

Figure 1The alt text for this image may have been generated using AI.

H84T BanLec potency against VZV, HCMV, and HSV-1 in cultured cells. Cell-free viruses were added to cell monolayers at 37 °C, and H84T BanLec or positive control antiviral compounds were added at 0 h post-inoculation (HPI) or 2 HPI. The antiviral compounds remained in the culture medium until virus yield was measured by bioluminescence imaging. ARPE-19 cells or HFF cells were infected with VZV for 3 days (A, B), HFF cells were infected with HCMV for 7 days (C), and Vero cells were infected with HSV-1 for 2 days (D). Virus yield was calculated from the average Total Flux of untreated wells divided by the average Total Flux of the treated wells. H84T BanLec cytotoxicity was measured using a neutral red dye uptake assay in Vero cells treated for 48 h (D) and HFFs or ARPE-19 cells treated for 72 h (A–C). Each point represents the mean ± SD. N = 3–6 biological replicates.

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