Table 3 Diagnostic accuracy of montreal cognitive assessment (MoCA), corneal confocal microscopy (CCM) and cingulate gyrus volume for schizophrenia.

From: Abnormal corneal nerve morphology and brain volume in patients with schizophrenia

 

AUC % (95% Cl)

Cutoff value

Sensitivity %

Specificity %

P-value

MoCA score

70 (57–84)

≤ 27

73

58

< 0.01

CNFD (fibers/mm2)

79 (68–91)

≤ 36

79

58

< 0.0001

CNBD (branches/mm2)

88 (79–97)

≤ 61

82

85

< 0.0001

CNFL (mm/mm2)

88 (79–96)

≤ 21

79

81

< 0.0001

CNBD:CNFD ratio

84 (74–95)

≤ 1.9

85

81

< 0.0001

Cingulate gyrus (ICV %)

73 (54–92)

≤ 0.84

61

80

< 0.05

  1. AUC area under the curve, CNFD corneal nerve fiber density, CNBD branch density, CNFL fiber length.
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