Figure 4
From: Aluminium co-localises with Biondi ring tangles in Parkinson’s disease and epilepsy
Aluminium in Biondi inclusions co-deposited with phosphorylated tau (pTau) in epithelial cells lining the choroid plexus of a 67-year-old female donor with Parkinson’s disease. (a) Autofluorescence highlighting intracellular lipofuscin. (b) Biondi inclusions (white arrows) positive for aluminium (Al, orange). (c) AT8 immunolabelled pTau (black arrows). (d) Merging of the brightfield and lumogallion fluorescence channels reveal that Biondi inclusions and aluminium are adjacently located in the same cells. Asterisks denote magnified inserts. Magnification: × 400, scale bars: 50 µm.
