Table 4 Number and proportion of RLS cases and controls with high c-aAb (IL-1α, IL-6, IL-10, IFN-α and GM-CSF -specific autoantibodies).

From: Chronic inflammation markers and cytokine-specific autoantibodies in Danish blood donors with restless legs syndrome

C-aAb

N

N cases

N controls

N cases with high c-aAba

N controls with high c-aAba

P-valueb

IL-1α

1471

73

1398

1 ≤ n ≤ 5 (1.4% ≤ n ≤ 6.8%)c

13 (0.9%)

0.168

IL-6

1477

75

1402

0 (0.0%)

15 (1.1%)

1

IL-10

1464

73

1391

0 (0.0%)

14 (1.0%)

1

IFN-α

1476

75

1401

1 ≤ n ≤ 5 (1.3% ≤ n ≤ 6.7%)c

12 (0.9%)

0.037

GM-CSF

1458

73

1385

0 (0.0%)

15 (1.1%)

1

  1. aHigh c-aAb is classified as having a c-aAb level above the 99th percentile of the given c-aAb dataset.
  2. bStatistical significant difference tested through Fisher’s exact test.
  3. cThe number of RLS cases with high c-aAb (either for IL-1α or IFN-α) is between 1 and 5. Local data confidentiality protection policies prohibit the exact reporting of observations ≤ 5.
  4. Significant values are in [bold].
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