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Figure 1

From: A new animal model of atrophy–hypertrophy complex and liver damage following Yttrium-90 lobar selective internal radiation therapy in rabbits

Figure 1The alternative text for this image may have been generated using AI.

Experimental design. (A) Liver anatomy of the rabbit, subdivided into four main lobes. These are the caudal lobe (CL) and three cranial lobes (CrLs): the right (RL), medial left (LM) and lateral (LL) left lobes, each supplied by branches of the arterial and portal venous system. This figure is reprinted from J. Surg. Res. 2011;171:486–9419, with permission from Elsevier. (B) Axial view of a contrast enhanced CT performed in a rabbit. Manual delineation of CrLs and CL for volumetry quantification. (C) Experimental design. Four experimental groups of animals were treated with 90Y-microspheres or non-loaded microspheres. Radiation toxicity, liver function, liver volume by CT scan, histological examination and gene expression involved in inflammation, regeneration and differentiation, were evaluated at different time points, as indicated in the text. (D) Four animals received fluorine-18 labelled resin microspheres, to evaluate the anatomical distribution and confirm selectivity of the delivery in CrLs while sparing of the CL. MicroPET images showed deposition in the CrLs, no CL deposition neither lung activity was observed.

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