Table 2 Logistic regression analysis comparing groups within one year and one or more years after injury.

From: Extracellular vesicle neurofilament light is elevated within the first 12-months following traumatic brain injury in a U.S military population

 

IC versus smcTBI

mTBI versus smcTBI

Odds Ratios

SE

p

Odds Ratios

SE

p

Within one year after injury

 

EV NfL

AUC

3.78

0.44

0.002

2.55

0.33

0.004

82.5%

95% CI 71.59–93.44%

78.2%

95% CI 66.2–90.12%

 

EV GFAP

AUC

3.36

0.64

0.058

1.92

0.52

0.212

69.9%

95% CI 57.61–82.22%

67.7%

95% CI 56.03–79.45%

One or more years after injury

 

EV NfL

AUC

1.13

0.57

0.828

1.64

0.41

0.225

70.8%

95% CI 49.47–92.09%

70.4%

95% CI 53.48–87.23%

 

EV GFAP

AUC

0.36

0.80

0.200

1.44

0.59

0.537

74.4%

95% CI 58.7–90.1%

61.4%

95% CI 47.07–74.93%

  1. Logistic regression analysis was performed to compare biomarker differences among. Logistic regression models included demographics (age, gender, race) and time since injury when comparing a TBI group and the injured control group. When comparing two TBI groups, number of TBIS was also included in the model. Biomarker concentrations were natural log transformed. P values for significant predictors are marked in bold. Odds ratio, Standard errors (SE) and p values for NfL and GFAP in each model are shown. Area under the Receiver Operating Characteristic Curves (AUCs) for each model are also provided.
  2. IC, injured controls; mTBI, uncomplicated mild TBI; smcTBI, complicated mTBI, moderate TBI, and severe TBI combined; TBI, traumatic brain injury; TSI, time since injury (orthopedic injury or TBI); NfL, Neurofilament light chain; GFAP, glial fibrillary acidic protein.
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