Table 2 Cross-trait genetic correlations of COVID-19 on inclusion/exclusion of genomic regions associated with BMI and smoking.

From: Shared genomic architecture between COVID-19 severity and numerous clinical and physiologic parameters revealed by LD score regression analysis

Traits

COVID-19 critical illness (A2)

COVID-19 hospitalization (B2)

A2

A2⟂BMI

A2⟂Smoke

B2

B2⟂BMI

B2⟂Smoke

rg

P

rg

P

rg

P

rg

P

rg

P

rg

P

Physical measurement

BMI

0.200

1.51 × 10−5

0.165

2.37 × 10−3

0.171

3.07 × 10−4

0.343

1.99 × 10−8

0.280

1.82 × 10−5

0.292

1.42 × 10−6

Weight

0.169

1.24 × 10−4

0.138

9.60 × 10−3

0.145

2.24 × 10−3

0.269

7.23 × 10−7

0.211

6.86 × 10−4

0.223

4.23 × 10−5

Whole body fat mass

0.201

7.81 × 10−6

0.170

2.00 × 10−3

0.178

1.49 × 10−4

0.329

2.24 × 10−8

0.273

2.32 × 10−5

0.287

8.51 × 10−7

Medical condition

Shortness of breath walking on level ground

0.283

2.87 × 10−3

0.198

0.107

0.272

8.33 × 10−3

0.433

4.56 × 10−5

0.372

5.94 × 10−3

0.395

4.01 × 10−4

Diabetes diagnosed by doctor

0.254

7.10 × 10−4

0.202

0.032

0.252

1.95 × 10−3

0.309

3.39 × 10−5

0.225

0.018

0.256

8.00 × 10−4

Diagnoses—main ICD10: K57 Diverticular disease of intestine

0.297

4.31 × 10−4

0.228

0.019

0.315

6.64 × 10−4

0.380

1.66 × 10−5

0.305

2.84 × 10−3

0.355

2.01 × 10−4

Diseases of the digestive system

0.201

3.48 × 10−3

0.097

0.292

0.183

0.020

0.446

1.86 × 10−7

0.348

1.14 × 10−3

0.384

2.30 × 10−5

Diseases of the musculoskeletal system and connective tissue

0.243

4.84 × 10−4

0.121

0.170

0.223

5.96 × 10−3

0.338

3.54 × 10−6

0.174

0.038

0.272

4.62 × 10−4

Smoking

Current tobacco smoking

0.135

0.021

0.014

0.858

0.081

0.223

0.339

2.01 × 10−6

0.285

6.57 × 10−4

0.237

3.33 × 10−3

Exposure to tobacco smoke at home

0.404

1.67 × 10−4

0.358

0.013

0.470

1.16 × 10−3

0.470

1.73 × 10−5

0.418

7.79 × 10−3

0.429

4.62 × 10−3

Nutrient

Magnesium

− 0.389

2.28 × 10−3

− 0.411

0.015

− 0.407

1.81 × 10−3

− 0.364

5.17 × 10−3

− 0.378

0.035

− 0.335

0.013

Calcium

− 0.329

0.033

− 0.457

0.020

− 0.347

0.017

− 0.222

0.137

− 0.340

0.067

− 0.219

0.121

Retinol

− 0.591

0.041

− 0.888

0.027

− 0.484

0.081

− 0.588

0.029

− 1.00

0.018

− 0.473

0.076

Vitamin E

− 0.527

2.16 × 10−3

− 0.883

0.010

− 0.540

1.26 × 10−3

− 0.528

3.10 × 10−3

− 0.804

0.022

− 0.484

5.08 × 10−3

Blood Assay

Albumin (g/L)

− 0.119

0.026

− 0.071

0.229

− 0.128

0.017

− 0.161

0.011

− 0.086

0.225

− 0.156

0.020

Apoliprotein A (g/L)

− 0.134

6.17 × 10−3

− 0.093

0.138

− 0.126

0.016

− 0.118

0.024

− 0.061

0.369

− 0.101

0.047

C-reactive protein (mg/L)

0.187

1.88 × 10−4

0.139

0.015

0.218

1.50 × 10−4

0.278

3.04 × 10−4

0.237

2.79 × 10−4

0.294

2.98 × 10−5

HDL cholesterol

− 0.174

5.20 × 10−4

− 0.126

0.048

− 0.166

1.60 × 10−3

− 0.164

2.25 × 10−3

− 0.097

0.161

− 0.141

6.93 × 10−3

High light scatter reticulocyte count

0.153

7.13 × 10−4

0.163

5.33 × 10−4

0.132

6.74 × 10−3

0.208

1.23 × 10−5

0.191

1.83 × 10−3

0.151

4.73 × 10−3

High light scatter reticulocyte percentage

0.155

4.13 × 10−4

0.168

1.78 × 10−4

0.131

5.68 × 10−3

0.209

7.66 × 10−6

0.198

8.04 × 10−4

0.150

5.12 × 10−3

IGF-1 (nmol/L)

− 0.148

4.99 × 10−3

− 0.155

0.017

− 0.153

5.64 × 10−3

− 0.090

0.077

− 0.116

0.064

− 0.083

0.118

Immature reticulocyte fraction

0.173

1.58 × 10−3

0.156

0.010

0.155

6.05 × 10−3

0.264

1.05 × 10−5

0.219

3.92 × 10−3

0.199

3.59 × 10−3

Platelet distribution width

− 0.108

0.017

− 0.130

0.011

− 0.109

0.020

− 0.038

0.440

− 0.060

0.256

− 0.038

0.432

  1. P-values in bold indicates P ≤ 1.30 × 10−4. COVID19_A2, very severe respiratory confirmed covid versus population including whole genomic regions; A2⟂BMI, very severe respiratory confirmed covid versus population with exclusion of genomic regions related to BMI; A2⟂Smoke, very severe respiratory confirmed covid versus population with exclusion of genomic regions related to smoking behaviors; COVID19_B2, hospitalized covid versus population including whole genomic regions; B2⟂BMI, hospitalized covid versus population with exclusion of genomic regions related to BMI; B2⟂Smoke, hospitalized covid versus population with exclusion of genomic regions related to smoking behaviors.
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