Figure 3 | Scientific Reports

Figure 3

From: Astrocytes deficient in circadian clock gene Bmal1 show enhanced activation responses to amyloid-beta pathology without changing plaque burden

Figure 3

Bmal1 deletion in astrocytes does not affect Aβ deposition in APP/PS1 mice. Images of brain sections (left) and percent area quantification (right) from 4-month-old old BMAL1 aKO; APP/PS1-21 mice and Cre- controls stained for GFAP (A), fibrillar Aβ (X34, B), total Aβ (HJ3.4b, C), dystrophic neurites (LAMP2, normalized to X34 area, D), and microglia (Iba1, E) (n = 6–10 mice per group, scale bars = 500 µm). (F) ELISA measurements of Aβ 1–42 in PBS- and Guanidine-soluble fractions from cortex (n = 8 mice per group). * = p < 0.05 by T-test.

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