Figure 4 | Scientific Reports

Figure 4

From: Astrocytes deficient in circadian clock gene Bmal1 show enhanced activation responses to amyloid-beta pathology without changing plaque burden

Figure 4

Bmal1 deletion in astrocytes does not affect Aβ deposition in APPNL-G-F/wt. (A–D) Images of brain sections from 9.5-month-old BMAL1 aKO; APPNL-G-F/WT knock-in mice and Cre- controls stained for GFAP(A), fibrillar Aβ (X34, B), total Aβ (HJ3.4b, C), and dystrophic neurites (LAMP2, D) (scale bars = 500 µm). Quantifications are percent area per cortex or hippocampus. n = 7–8 mice per group. *** = p < 0.0005, **** = p < 0.0001 by T-test.

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