Figure 4
From: p38 activation occurs mainly in microglia in the P301S Tauopathy mouse model
p38 activation occurs mainly in microglial cells of the hippocampus of the P301S mouse. (A) Representative images showing p38 activation (pp38. Green) in different cell populations (neurons (NeuN. White), astrocytes (GFAP. Cyan) and microglia (Iba1. Red)) of the cortex and hippocampus of 12-month-old animals. Note that pp38 shows punctate staining in the soma of neurons while it presents a strong signal in the nucleus of glia, especially microglia. (B) Quantification of pp38 intensity in each cell population. n = 13 (6–7 mice per group). Graph shows mean ± SEM. ##p < 0.01; ###p < 0.001; ***p < 0.001 from two-way ANOVA. †††p < 0.001 from Student’s t-test (two-tailed). Scale bar: 25 µm. GL: granular layer, h: hilus.
