Figure 5
From: p38 activation occurs mainly in microglia in the P301S Tauopathy mouse model
Rod microglia in the P301S mouse show lower levels of p38 activation. (A) Representative image of rod microglia in the cortex of a 12-month-old P301S mouse. White and blue dashed boxes correspond to the amplified sections (B and C). Note that rod microglia show lower levels of pp38 (white arrows) compared with other microglial subpopulations (blue arrows). (D) Number of rod microglia in the hippocampus and cortex of 12-month-old mice. ***p < 0.001 from two-way ANOVA. (E) Quantification of pp38 intensity in rod microglia. **p < 0.01 from Student’s t-test (two-tailed). n = 13 (6–7 mice per group). Graphs show mean ± SEM. Scale bars: 50 µm.
