Figure 4 | Scientific Reports

Figure 4

From: Development of SARS-CoV2 humoral response including neutralizing antibodies is not sufficient to protect patients against fatal infection

Figure 4

Kinetics of antibody responses against SARS-CoV-2 in recovered COVID-19 patients. Recovered COVID-19 patients were individuals infected by SARS-CoV2 more than 2 months ago who were cured. (a,h) Percentage of seropositivity (a) and percentage of patients with neutralizing antibodies (h) in recovered patients according to the time between symptom onset and sample collection. Seropositivity corresponds to the presence of anti-RBD and/or anti-N antibodies in serum/plasma. The number of patients in each group is shown in Table 1. (b–g,i) Titers of anti-RBD IgG (b), IgM (c) and IgA (d), titers of anti-N IgG (e), IgM (f) and IgA (g) and spike-pseudotyped lentiviral neutralization (i) in recovered patients according to the time between symptom onset and sample collection. Each dot represents one sample. Dashed line represents the positivity threshold. The preferred model for best fit curve (solid line) was assessed by an extra sum-of-squares F test and is a semi-log line. The Spearman’s correlation coefficient (r) is not significant for all graphs.

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