Table 2 Univariate analyses of risk factors for 5-year OS and RFS.

From: The prognostic significance of apical lymph node metastasis in patients with high-risk stage III colon cancer

Variables

5-year OS

RFS

HR

95%CI

p value

HR

95%CI

p value

Age, ≥ 65 years

1.3

0.72–2.4

0.37

0.85

0.54–1.3

0.47

Sex, Male

1.3

0.88–1.8

0.21

1.2

0.78–1.9

0.37

BMI ≥ 25

1.2

0.64–2.4

0.54

1.0

0.59–1.8

0.93

PS, ≥ 1

1.1

0.47–2.6

0.81

0.68

0.29–1.6

0.36

CEA, ≥ 5 ng/dl

1.6

0.89–2.7

0.12

1.8

1.1–2.8

0.011

CA19-9, ≥ 37 ng/dl

1.8

0.96–3.3

0.07

1.7

1.0–2.8

0.047

Tumor size, ≥ 50 mm

1.2

0.71–2.1

0.46

1.3

0.82–2.0

0.28

Location, Right-side

1.2

0.68–2.1

0.53

1.1

0.67–1.7

0.82

Differentiation, poorly or mucinous

2.8

1.5–5.2

0.002

1.4

0.77–2.5

0.28

pT, T4

1.3

0.66–2.5

0.46

1.5

0.87–2.6

0.15

pN, N2

1.2

0.68–2.0

0.57

1.1

0.72–1.7

0.62

LN ratio, ≥ 0.15

2.0

1.1–3.5

0.019

1.5

0.95–2.3

0.086

lymphatic involvement,

1.1

0.56–2.0

0.88

0.76

0.47–1.2

0.25

vascular invasion

1.4

0.70–2.6

0.37

1.4

0.82–2.3

0.24

APN metastasis

3.2

1.5–6.8

0.003

3.0

1.6–5.6

 < 0.001

Adjuvant chemotherapy

0.64

0.37–1.1

0.11

0.69

0.44–1.1

0.10

  1. OS: overall survival, RFS: relapse free survival, HR: hazard ratio, CI: confidence interval, BMI: body mass index, calculated as weight in kilograms divided by height in meters squared, PS: performance status, CEA: carcinoembryonic antigen, CA19-9: carbohydrate antigen 19-9, pT: pathological T stage, pN: pathological N stage, LN: lymph node, LN ratio: the number of metastatic LN divided by that of retrieved LN, APN: apical lymph node.
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