Table 1 Top 20 enriched GO terms for each comparison.

From: Transcriptional changes in dendritic cells underlying allergen specific induced tolerance in a mouse model

 

Antigen-only

Tolerant/2 nM

Desensitized/5 nM

Term (adjusted P-value | mean log2Fold-change)

Term (adjusted P-value | mean log2Fold-change)

Term (adjusted P-value | mean log2Fold-change)

Immune general

Negative regulation of immune system process (3.75e-13 |− 1.60)

Negative regulation of immune system process (0.002 |− 1.88)

Regulation of hemopoiesis (0.003 |− 1.04)

Negative regulation of immune system process (0.002 |− 0.59)

Defense response to Gram-positive bacterium (0.008 |− 1.42)

Chronic inflammatory response (0.01 |− 1.12)

Regulation of hemopoiesis (0.003 |− 0.25)

Immune cells processes

Regulation of leukocyte differentiation (2.61e − 13 |− 1.48)

Lymphocyte differentiation (3.74e − 13 |− 1.29)

Leukocyte cell–cell adhesion (2.07e − 12 |− 1.48)

Regulation of cell–cell adhesion (3.70e − 12 |− 1.58)

Regulation of T cell activation (9.62e − 12 |− 1.43)

Positive regulation of cell activation (4.26e − 11 |− 1.52)

Negative regulation of leukocyte activation (2.42e − 10 |− 1.46)

Leukocyte proliferation (4.64e − 09 |− 1.34)

Regulation of leukocyte proliferation (6.29e − 09 |− 1.31)

Alpha–beta T cell activation (6.87e − 09 |− 1.40)

Myeloid leukocyte activation (6.93e − 09 |− 1.41)

Regulation of lymphocyte proliferation (6.93e − 09 |− 1.43)

Cell chemotaxis (6.93e − 09 |− 1.65)

Lymphocyte proliferation (1.59e − 08 |− 1.42)

Immune receptor activity (2.02e − 08 |− 1.50)

Glucocorticoid receptor binding (3.70e − 05 |− 1.67)

Regulation of cell–cell adhesion (0.002 |− 0.89)

Regulation of T cell activation (0.002 |− 0.34)

Leukocyte cell –cell adhesion (0.002 |− 0.41)

Alpha–beta T cell activation (0.005 |− 0.72)

Regulation of lymphocyte proliferation (0.0008 |− 0.46)

Regulation of mononuclear cell proliferation (0.0008 |− 0.46)

Positive regulation of leukocyte activation (0.003 |− 0.77)

Positive regulation of cell activation (0.003 |− 0.77)

Lymphocyte proliferation (0.003 |− 0.46)

Mononuclear cell proliferation (0.003 |− 0.46)

Leukocyte cell–cell adhesion (0.003 |− 0.70)

Regulation of leukocyte cell–cell adhesion (0.009 |− 0.39)

Regulation of T cell activation (0.01 |− 0.65)

Alpha–beta T cell activation (0.01 |− 0.80)

Cytokines related

Positive regulation of cytokine production (9.44e − 14 |− 1.53)

Negative regulation of cytokine production (2.75e − 09 |− 1.56)

Cytokine binding (3.40e − 08 |− 1.52)

Cytokine binding (2.58e − 06 |− 1.49)

Cytokine receptor activity (1.04e − 05 |− 0.51)

C–C chemokine receptor activity (0.002 |− 0.75)

G protein-coupled chemoattractant receptor activity (0.002 |− 0.75)

Chemokine receptor activity (0.002 |− 0.75)

Positive regulation of cytokine production (0.002 |− 1.57)

Negative regulation of cytokine production (0.003 |− 2.37)

Secretory granule (0.0002 |− 1.49)

Regulation of interleukin-12 production (0.01 |− 1.45)

Interleukin-12 production (0.01 |− 1.45)

Cellular metabolism & signaling

 

Negative regulation of phosphorylation (0.002 |− 1.08)

Response to unfolded protein (0.002 |− 0.66)

Negative regulation of transferase activity (0.002 |− 1.14)

Negative regulation of MAPK cascade (0.002 |− 0.98)

Positive regulation of cellular catabolic process (0.002 |− 0.99)

DNA-binding transcription factor binding (0.004 |− 1.34)

Negative regulation of cysteine − type endopeptidase activity (0.008 |− 1.80)

Negative regulation of hydrolase activity (0.009 |− 1.67)

Positive regulation of tyrosine phosphorylation of STAT protein (0.01 | 0.74)

Other

Regulation of vasculature development (7.60e − 09 |− 1.83)

  
  1. Adjusted P-value and mean log2FC for each team are shown. Terms unique for each comparison top 20 enriched terms are in bold.
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