Scheme 1
From: A disintegrin derivative as a case study for PHIP labeling of disulfide bridged biomolecules
Illustration of the Intercalation-hydrogenation strategy to boost signal intensity in NMR experiments using the ethynyl-containing label 2. Additionally, the biochemical relevant “K”GD-amino acid sequence ("Lys"-Gly-Asp) is highlighted. [We followed the usual nomenclature of the binding motif although it should read homo-R-G-D instead of K-G-D]48,49.
