Figure 2 | Scientific Reports

Figure 2

From: Inhibition of spleen tyrosine kinase decreases donor specific antibody levels in a rat model of sensitization

Figure 2

Fostamatinib treatment prevented production of donor specific antibody. T Lymphocyte crossmatch was performed to detect DSA levels in sensitized fostamatinib treated and vehicle treated LEW rats. (A) IgM, (B) IgG and (C–F) IgG subset production was inhibited by fostamatinib treatment at all time points measured (n = 6 rats/group). *P ≤ 0.05, **P ≤ 0.01. Blue Filled circle—vehicle, red filled triangle—fostamatinib.

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