Table 4 Linear regression of the relative abundance of oral OTUs on carbohydrate intake and glycemic load with beta-coefficients (ß), standard errors (SE), and associated p-value for each dietary variable. (n = 1,204).

From: Dietary carbohydrate intake is associated with the subgingival plaque oral microbiome abundance and diversity in a cohort of postmenopausal women

Species/OTU	Crude		Model 1*		Model 2^†		Partial r ^§
Species/OTU	ß (SE)	p-Value^‡	ß (SE)	p-Value^‡	ß (SE)	p-Value^‡	Partial r ^§
Total carbohydrates (% kcals)
Sphingomonas HOT 006	0.016 (0.004)	< .0001	0.015 (0.004)	0.0003	0.015 (0.004)	0.0004	0.106
Rothia dentocariosa	0.037 (0.009)	< .0001	0.030 (0.009)	0.001	0.031 (0.009)	0.001	0.096
Rothia mucilaginosa	0.033 (0.008)	< .0001	0.026 (0.008)	0.002	0.027 (0.008)	0.002	0.093
*Streptococcus mutans*	0.046 (0.012)	0.0001	0.051 (0.012)	< .0001	0.056 (0.012)	< .0001	0.123
Brevundimonas diminuta	0.016 (0.004)	0.0003	0.016 (0.005)	0.0006	0.016 (0.005)	0.0005	0.101
Glycemic load (g/1,000 Kcals)
*Streptococcus mutans*	0.039 (0.009)	< .0001	0.041 (0.009)	< .0001	0.044 (0.009)	< .0001	0.138
*Sphingomonas HOT 006*	0.012 (0.003)	< .0001	0.012 (0.003)	< .0001	0.012 (0.003)	< .0001	0.117
Streptococcus salivarius	0.024 (0.006)	0.0002	0.022 (0.007)	0.0009	0.024 (0.007)	0.0002	0.098
Brevundimonas diminuta	0.012 (0.003)	0.0002	0.012 (0.003)	0.0003	0.012 (0.003)	0.0002	0.107
*Scardovia wiggsiae*	0.024 (0.007)	0.0003	0.026 (0.007)	0.0002	0.028 (0.007)	< .0001	0.111
Total fiber (g/1,000 Kcals)
Actinomyces HOT 171	0.092 (0.021)	< .0001	0.071 (0.022)	0.001	0.065 (0.022)	0.003	0.095
Ottowia HOT 894	0.090 (0.023)	< .0001	0.080 (0.023)	0.0007	0.084 (0.024)	0.0004	0.100
Rothia aeria	0.090 (0.025)	0.0003	0.053 (0.025)	0.036	0.050 (0.025)	0.048	0.062
Lautropia mirabilis	0.086 (0.024)	0.0004	0.052 (0.024)	0.034	0.049 (0.025)	0.046	0.063
Insoluble fiber (g/1,000 kcals)
Actinomyces HOT 171	0.123 (0.028)	< .0001	0.096 (0.029)	0.0009	0.088 (0.029)	0.002	0.098
Ottowia HOT 894	0.118 (0.030)	< .0001	0.104 (0.030)	0.0007	0.110 (0.031)	0.0004	0.100
Neisseria elongata	0.132 (0.036)	0.0003	0.110 (0.037)	0.003	0.111 (0.037)	0.003	0.087
Lactose (% Kcals)
*Aggregatibacter segnis*	− 0.117 (0.028)	< .0001	− 0.125 (0.028)	< .0001	− 0.124 (0.028)	< .0001	− 0.129
Sucrose (% Kcals)
*Streptococcus mutans*	0.201 (0.035)	< .0001	0.198 (0.035)	< .0001	0.207 (0.035)	< .0001	0.163
*TM7_[G-1] HOT 346*	− 0.104 (0.027)	0.0001	− 0.105 (0.027)	0.0001	− 0.105 (0.027)	0.0001	− 0.113
*Leptotrichia HOT 223*	− 0.094 (0.025)	0.0001	− 0.098 (0.025)	0.0001	− 0.097 (0.025)	0.0001	− 0.113
*Streptococcus lactarius*	0.080 (0.021)	0.0002	0.078 (0.022)	0.0003	0.083 (0.022)	0.0001	0.106
Leptotrichia buccalis	− 0.111 (0.030)	0.0002	− 0.108 (0.030)	0.0003	− 0.109 (0.030)	0.0003	− 0.105
Streptococcus intermedius	0.109 (0.030)	0.0003	0.113 (0.030)	0.0002	0.111 (0.030)	0.0002	0.111
Streptococcus parasanguinis_II	0.103 (0.028)	0.0003	0.097 (0.028)	0.0005	0.101 (0.028)	0.0003	0.102
Leptotrichia HOT 498	− 0.101 (0.029)	0.0004	− 0.107 (0.029)	0.0002	− 0.109 (0.029)	0.0002	− 0.108
Brevundimonas diminuta	0.047 (0.013)	0.0004	0.043 (0.013)	0.001	0.043 (0.013)	0.001	0.095
Galactose (% Kcals)
Leptotrichia goodfellowii	2.741 (0.720)	0.0001	2.352 (0.725)	0.001	2.323 (0.727)	0.001	0.095

*Model 1 adjusted for age, race and ethnicity frequency of flossing, frequency of brushing, frequency of dental visits, smoking status, pack-years of smoking, and antibiotic use. OTUs are ranked for each carbohydrate or glycemic load by the significance of the p-values for the beta regression coefficients in the crude model. Sample size reduced to n = 1,172 for Model 1.
^†Adjusted for all covariates in Model 1 plus further adjustment for body mass index (BMI) and diabetes status. Sample size stayed at n = 1,172 for Model 2.
^‡P-values are bolded when a p-value is significant after a Bonferroni correction is applied (0.05/245 = 0.0002). In other words, a p-value < 0.0002 will remain statistically significant after an adjustment for multiple comparisons. Only OTUs with p-values for crude models < 0.0005 are shown (no crude models 0.0005 or higher became statistically significant with adjustment).
^§Partial r for each carbohydrate variable and glycemic load in Model 1.

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Table 4 Linear regression of the relative abundance of oral OTUs on carbohydrate intake and glycemic load with beta-coefficients (ß), standard errors (SE), and associated p-value for each dietary variable. (n = 1,204).

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