Figure 1

A schematic illustration of the regulation of SKP2 ubiquitination by APC/C (E3 ubiquitin ligase) and USP10/USP13 (deubiquitinating enzymes), and SKP2-mediated ubiquitination of p27.

A schematic illustration of the regulation of SKP2 ubiquitination by APC/C (E3 ubiquitin ligase) and USP10/USP13 (deubiquitinating enzymes), and SKP2-mediated ubiquitination of p27.