Figure 3 | Scientific Reports

Figure 3

From: A gene signature consisting of ubiquitin ligases and deubiquitinating enzymes of SKP2 is associated with clinical outcome in breast cancer

Figure 3

Correlation between Skp2 ubiquitination levels and SKP2 mRNA levels. Correlation between (1) the log fold changes (LFCs) of the genes differentially expressed between the high- and low-SKP2 ubiquitination groups (y-axis) and (2) the LFCs of the genes differentially expressed between high and low SKP2 copy number (x-axis). Analyses were performed on a dataset in aggregate (n = 728) and on three major subtypes separately: luminal (n = 566), HER2 (n = 27), and triple-negative BC (TNBC) (n = 62). Number of genes in each dataset = 20,501. Subtypes are defined as in Fig. 2. Spearman’s method was used to calculate the rank correlation. The results of the limma linear-model fits, including all 20,501 genes, can be found in Supplementary File S1.

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