Figure 2

False-positive. Example of a ‘false-positive’, an area of partial demyelination or remyelination that has been scored as a cortical lesion on all (conventional and artificial) DIR sequences. The panels depict the conventionally acquired DIR image in axial fashion (A), a coronal image as a reference for the histopathological sample (B), the histopathological sample that has been stained for myelin (C), 3D-T₁ (D), artificial DIR generated from 3D-T₁ and PD/T₂ (E), and artificial DIR generated from 3D-T₁ and FLAIR (F). The partial demyelination/remyelination area is indicated by the red arrow on all panels (generated using Adobe Illustrator—Adobe Inc., 2019. Adobe Illustrator,