Table 2 Diagnostic accuracy of faecal biomarkers and their comparisons.

From: Comparison of faecal protein biomarkers' diagnostic accuracy for colorectal advanced neoplasms: a systematic review and meta-analysis

Testb

P-Se (95% CI) (% I2)

P-Sp (95% CI) (% I2)

P-LR+ (95% CI)

P-LR− (95% CI)

P-DOR (95% CI)

AUC (95% CI)

TE

PB

CAa

Diagnostic accuracy of faecal protein biomarkers

Colorectal cancer

iFOBT

0.83 (0.74–0.89) (87.6%)

0.86 (0.81–0.90) (95.2%)

6.10 (4.5–8.2)

0.20 (0.13–0.31)

30 (18–49)

0.91 (0.89–0.94)

0.32

0.72

A

PK-M2

0.82 (0.76–0.87) (82.1%)

0.73 (0.65–0.80) (95.1%)

3 (2.3–4.0)

0.24 (0.18–0.33)

12 (8–20)

0.85 (0.82–0.88)

0.51

0.73

A

FC

0.85 (0.80–0.89) (77.9%)

0.65 (0.57–0.71) (97.5%)

2.4 (2.0–2.9)

0.23 (0.18–0.30)

10 (7–15)

0.85 (0.81–0.87)

0.40

0.53

A

Advanced adenoma

iFOBT

0.53 (0.35–0.70) (82.3%)

0.81 (0.70–0.89) (97%)

2.8 (1.7–4.4)

0.58 (0.41–0.83)

5 (2–10)

0.74 (0.70–0.78)

0.66

0.05

NA

PK-M2

0.46 (0.34–0.58) (84.7%)

0.64 (0.48–0.77) (98.4)

1.3 (0.8–2.0)

0.85 (0.64–1.13)

1 (1–3)

0.54 (0.49–0.58)

0.33

0.83

NA

FC

0.45 (0.35–0.55) (84.2%)

0.56 (0.45–0.66) (98.5%)

1.0 (0.9–1.2)

0.99 (0.89–1.10)

1 (1–1)

0.50 (0.45–0.54)

0.58

0.10

NA

Advanced neoplasm

iFOBT

0.72 (0.58–0.83) (90.2%)

0.88 (0.80–0.92) (96%)

5.9 (4.1–8.4)

0.31 (0.21–0.47)

19 (12–28)

0.88 (0.85–0.91)

0.49

0.53

A

PK-M2

0.68 (0.63–0.73) (56.72%)

0.76 (0.65–0.84) (95.9%)

2.9 (2.0–4.2)

0.42 (0.36–0.48)

7 (4–11)

0.73 (0.69–0.77)

 < 0.01

0.22

A

FC

0.70 (0.58–0.80) (92.3%)

0.59 (0.49–0.70) (98.3%)

1.7 (1.4–2.2)

0.50 (0.36–0.70)

3 (2–6)

0.69 (0.65–0.73)

0.78

0.01

NA

Comparison

RDOR (95% CI)

P value

       

Comparison of faecal biomarker diagnostic accuracies

       

Colorectal cancer

       

iFOBT versus PK-M2

2.49 (1.12–5.54)

0.02

       

iFOBT versus FC

2.96 (1.50–5.85)

 < 0.01

       

PK-M2 versus FC

1.07 (0.56–2.05)

0.83

       

Advanced neoplasm

       

iFOBT versus PK-M2

2.84 (0.88–9.21)

0.07

       

iFOBT versus FC

3.44 (1.22–9.68)

0.02

       

PK-M2 versus FC

1.03 (0.35–3.04)

0.95

       

Advanced neoplasm

       

iFOBT versus PK-M2

2.70 (1.42–5.12)

 < 0.01

       

iFOBT versus FC

6.41 (2.75–14.96)

 < 0.01

       

PK-M2 versus FC

1.70 (0.75–3.83)

0.19

       
  1. aP-Se pooled-sensitivity, P-Sp pooled-specificity, P-LR pooled-likelihood ratio, P-DOR pooled-diagnostic odds ratio, AUC area under the curve, TE P value of threshold effect, PB P value of publication bias, CA clinical applicability.
  2. biFOB immunochemical faecal occult blood tests, PK-M2 pyruvate kinase-M2, FC faecal calprotectin, A applicable, NA not applicable, RDOR relative DOR.
Back to article page