Table 3 Target protein and associated pathways.

Acetylcholinesterase (AChE)

(Cartwright blood group)^a

43

27

Glycerophospholipid metabolism, cholinergic synapse

PLA2G1B

5319

14

Glycerophospholipid metabolism, ether lipid metabolism arachidonic acid metabolism, linoleic acid metabolism, alpha-Linolenic acid metabolism, metabolic pathways, RAS signaling pathway, vascular smooth muscle contraction, pancreatic secretion, fat digestion and absorption

LPCAT1

79,888

6

Glycerophospholipid metabolism, ether lipid metabolism, metabolic pathways

Ecto-5'-nucleotidase (NTE5)

4907

5

Purine metabolism, pyrimidine metabolism, nicotinate and nicotinamide metabolism, metabolic pathways

Fibroblast growth factor receptor 2 (FGF-2)^a

2263

4

EGFR tyrosine kinase inhibitor resistance, MAPK signaling pathway, RAS signaling pathway, Rap1 signaling pathway, endocytosis, PI3K-Akt signaling pathway, signaling pathways regulating pluripotency of stem cells, regulation of actin cytoskeleton, pathways in cancer, prostate cancer, gastric cancer, central carbon metabolism in cancer

FR-β

2350

4

Antifolate resistance, endocytosis

FR-γ

2352

4

Antifolate resistance, endocytosis

NNMT

4837

4

Nicotinate and nicotinamide metabolism, metabolic pathways

QPRT

23,475

4

Nicotinate and nicotinamide metabolism, metabolic pathways

DAB adaptor protein 2

1601

3

Endocytosis

Diacylglycerol kinase alpha

1606

2

Glycerolipid metabolism, glycerophospholipid metabolism, metabolic pathways, phosphatidylinositol signaling system, phospholipase D signaling pathway, choline metabolism in cancer

Purine nucleoside phosphorylase

4860

2

Purine metabolism, pyrimidine metabolism, nicotinate and nicotinamide metabolism, metabolic pathways

Phosphate cytidylyltransferase 1, choline, alpha

5130

2

Phosphonate and phosphinate metabolism, glycerophospholipid metabolism, metabolic pathways, choline metabolism in cancer

Phospholipase D1

5337

2

Glycerophospholipid metabolism, ether lipid metabolism, metabolic pathways, RAS signaling pathway, cAMP signaling pathway, sphingolipid signaling pathway, phospholipase D signaling pathway, endocytosis, Fc γ R-mediated phagocytosis, glutamatergic synapse, gonadotropin-releasing hormone (GnRH) signaling pathway, parathyroid hormone synthesis/secretion/action, pathways in cancer, pancreatic cancer, choline metabolism in cancer

Phospholipase D2

5338

2

Glycerophospholipid metabolism, ether lipid metabolism, metabolic pathways, RAS signaling pathway, cAMP signaling pathway, sphingolipid signaling pathway, phospholipase D signaling pathway, endocytosis, Fc γ gamma R-mediated phagocytosis, glutamatergic synapse, GnRH signaling pathway, parathyroid hormone synthesis, secretion and action, pathways in cancer, pancreatic cancer, choline metabolism in cancer

Phosphate cytidylyltransferase 1, choline, β

9468

2

Phosphonate and phosphinate metabolism, glycerophospholipid metabolism, metabolic pathways, choline metabolism in cancer

NTE5

22,978

2

Purine metabolism, pyrimidine metabolism, nicotinate and nicotinamide metabolism, metabolic pathways

Phospholipase A2 group IIE

30,814

2

Glycerophospholipid metabolism, ether lipid metabolism, arachidonic acid metabolism, linoleic acid metabolism, alpha-linolenic acid metabolism, metabolic pathways, RAS signaling pathway, vascular smooth muscle contraction, pancreatic secretion, fat digestion and absorption

Phosphoethanolamine/phosphocholine phosphatase 1

162,466

2

Glycerophospholipid metabolism, metabolic pathways

G protein-coupled receptor kinase 3

157

1

Chemokine signaling pathway, endocytosis, Hedgehog signaling pathway, glutamatergic synapse, olfactory transduction, morphine addiction

G protein-coupled receptor kinase 2

156

1

Chemokine signaling pathway, endocytosis, Hedgehog signaling pathway, glutamatergic synapse, olfactory transduction, morphine addiction

Arrestin β 2

409

1

MAPK signaling pathway, chemokine signaling pathway, endocytosis, Hedgehog signaling pathway, dopaminergic synapse, olfactory transduction, Relaxin signaling pathway, parathyroid hormone synthesis, secretion and action, GnRH secretion, morphine addiction

Choline O-acetyltransferase

1103

1

Glycerophospholipid metabolism, cholinergic synapse

RAB7A, member RAS oncogene family

7879

1

Mitophagy–animal, autophagy–animal, endocytosis, phagosome, Salmonella infection, amoebiasis, tuberculosis

Ectonucleotide pyrophosphatase/phosphodiesterase 1

5167

1

Purine metabolism, pyrimidine metabolism, starch and sucrose metabolism, riboflavin metabolism, nicotinate and nicotinamide metabolism, pantothenate and CoA biosynthesis, metabolic pathways