Figure 1 | Scientific Reports

Figure 1

From: Functional buffering via cell-specific gene expression promotes tissue homeostasis and cancer robustness

Figure 1

Genome-wide CEBU analysis using the C-score index. (A) Illustration of the cell-specific expression-buffering mechanism (CEBU). Cells with higher buffering gene (G2) expression (darker arrow) have stronger buffering potential, thereby lowering the essentiality of the buffered gene (G1). The illustration and cartoons are created using Adobe Illustrator. (B) C-score plot: the x-axis is the dependency score of the buffered gene (G1) and the y-axis is the expression level of the buffering gene (G2). G1 is considered as being potentially buffered by G2, as quantified by C-score, which is an adjusted correlation for a given gene based on the C-score plot. (C) Distribution of C-scores for all gene pairs (blue) and one of five randomly shuffled distributions (grey). The plot shows C-score between 0.4 and 0.6. The dashed lines indicate the C-score percentiles of 0.25, 0.35 and 0.45 for the all-gene-pair distribution.

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