Figure 2
Properties of high C-score gene pairs. (A) Enrichment for duplicated genes as C-scores increase (hypergeometric test). The dashed line denotes p-value of 0.05, where the corresponding C-score is 0.255. The red region (i.e., above the dashed line and equating to C-score > 0.255) indicates significant enrichment. The green region indicates lack of significance. (B,C) Functional enrichment of C-score gene pairs increases with C-score cutoff. (B) Percentage of C-score-identified non-duplicated and duplicated gene pairs with different C-score cut-offs. (C) Enrichment of pairs of genes annotated with the same gene ontology biological process (GO:BP) term or KEGG pathway in C-score gene pairs. Enrichment increases with C-score cut-off. (D) Enrichment of pairs of genes with annotated protein–protein interactions from STRING and within the same protein complex from CORUM among C-score gene pairs. Enrichment increases with C-score cut-off. (E) Left: the buffering gene network is composed of 6664 nodes and 42,754 edges with C-scores > 0.2536 visualized using Cytoscape (https://cytoscape.org/). Orange nodes represent buffered genes; grey nodes are buffering genes, and blue nodes are genes that are both buffered and buffering. Right: Clusters of GO-enriched biological functions in the buffering gene network. Numbers indicate the number of genes in the cluster.
