Figure 5
C-score-derived tissue-specific buffering capacity. (A) Illustration showing how cell-specific buffering capacities were derived from C-scores. Buffering capacity was calculated based on: (1) the regression line of the C-score for the gene pair; and (2) relative G2 expression (compared to that of all other cell lines) for the cell line of interest. See “Methods” for the formula for buffering capacity calculation. (B) Predictive performance shown as ROC curves for predicting genetic interactions using cell-specific buffering capacity. Prediction sets consist of 84 data-points (37 unique genetically interacting gene pairs) across 8 cell lines with a C-score cut-off of 0.25. (C) Mean buffering capacity for each tissue type (lower panel) and the corresponding proportion of enriched gene pairs for each region (upper panel).
