Figure 1

(a) In vivo imaging affords longitudinal assessment of the hind paws in the murine CIA model. (b) The acquired image is reconstructed using MI Labs software (https://www.milabs.com/u-ct/; Version: 12.0). (c) Following reconstruction, the image is reoriented using VivoQuant software (http://www.vivoquant.com/, Version: VivoQuant™ 2020) such that the metatarsals are vertically aligned and orthogonal to the cross-sectional plane in the z-direction. (d) The ROI, traversing 1.8 mm vertically, is selected in VivoQuant software by noting anatomical tarsal features.