Table 3 Potential key candidate proteins identified from the proteome.
Protein name | FC of HBF/LBF | P-value | FC of HIMF/LIMF | P-value | Functional analysis |
|---|---|---|---|---|---|
ACAA2 | 0.82 | 0.023 | 0.84 | 0.36 | Propanoate metabolism, fatty acid degradation, fatty acid metabolism |
ACAT1 | 0.71 | 0.043 | 0.96 | 0.87 | Propanoate metabolism, fatty acid degradation, fatty acid metabolism, synthesis and degradation of ketone bodies |
ALDH6A1 | 0.81 | 0.009 | 0.81 | 0.09 | Valine, leucine, and isoleucine degradation, propanoate metabolism, carbon metabolism, beta-alanine metabolism, metabolic pathways |
ACOX1 | 0.81 | 0.025 | – | – | Propanoate metabolism, fatty acid degradation, fatty acid metabolism, PPAR signaling pathway |
PCCB | 0.79 | 0.047 | 0.92 | 0.41 | Propanoate metabolism |
MMUT | 0.74 | 0.016 | 0.93 | 0.35 | Propanoate metabolism |
IDH3A | 0.83 | 0.003 | 0.97 | 0.80 | Carbon metabolism, metabolic pathways, citric acid cycle |
HMGCL | 0.79 | 0.048 | – | – | Valine, leucine, and isoleucine degradation, synthesis and degradation of ketone bodies, peroxisome, metabolic pathways, butanoate metabolism |
CPT1A | 1.38 | 0.035 | – | – | Fatty acid degradation, fatty acid metabolism, PPAR signaling pathway, adipocytokine signaling pathway, thermogenesis |
SDHD | 0.77 | 0.007 | 0.00 | 0.00 | Carbon metabolism, metabolic pathways, citric acid cycle, thermogenesis, Alzheimer’s disease |
ACSL4 | 1.20 | 0.006 | – | – | Fatty acid degradation, fatty acid metabolism, peroxisome, metabolic pathways, PPAR signaling pathway, adipocytokine signaling pathway |
TRIM55 | – | – | 0.81 | 0.022 | prostaglandin metabolism |
PTGR2 | 0.96 | 0.55 | 0.79 | 0.047 | Metabolism of lipids, Fatty acid metabolism, Arachidonic acid metabolism,Eicosanoid metabolism via lipooxygenases |
UBD | – | – | 2.39 | 0.008 | Proteasome binding, protein ubiquitination, positive regulation of apoptotic process |
