Figure 3 | Scientific Reports

Figure 3

From: Humanization of a strategic CD3 epitope enables evaluation of clinical T-cell engagers in a fully immunocompetent in vivo model

Figure 3

Characterization of thymus and spleens in hCD3E-epi mice. Spleen (a) and thymus (b) were weighed across WT littermate and hCD3E-epi 7-week old mice (n = 6). Weights are graphed as a percentage of total body weight. Each point represents an individual mouse. Results are shown as mean ± SD, ns, p > 0.05. Representative images of hCD3E-epi (c,e) and WT littermates (d,f) for both H&E and IHC staining. Similar histology and CD3E staining pattern were observed in thymi of hCD3E-epi and WT mice. (c,d) H&E staining (e,f) CD3E staining.

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