Figure 4
Healthy vs. tumor tissue quantification by svOCT and DCE-MRI. Significant differences in the microvasculature and corresponding DCE-MRI concentration–time curves were observed when comparing healthy and tumor tissue. (A) segmented depth-encoded svOCT microvascular map of healthy (bare skin) mouse and corresponding DCE-MRI Gd time concentration curve (B). (C) and (D) present analogous results for a tumor-bearing mouse. Gd time concentration curves and svOCT vascular metrics were calculated within a 1 \({\mathrm{mm}}^{3}\) volume of interest (blue dotted line) shown in (A) and (C). The solid blue line in (C) shows the tumor contour and the red line in (B) and (D) are the Toft’s model fits to the data. (A) and (C) were generated using MATLAB R2020A software (MathWorks, Inc., Natick, MA, USA).
