Table 5 Characteristics of Ext1/Ext2-associated MN in primary and secondary MN patients at the time of renal biopsy and treatment response.
Characteristics | Total | Primary | Secondary |
|---|---|---|---|
Number of patients | 17 | 9 | 8 |
Male; number (%) | 11 (64.7) | 5 (55.6) | 6 (75.0) |
Age, years; mean | 51.4 ± 13.3 | 54.2 ± 11.6 | 48.3 ± 15.2 |
Proteinuria (g/day) | 2.5 ± 2.3 | 2.8 ± 2.6 | 2.2 ± 2.1 |
Serum creatinine (mg/dl) | 0.8 ± 0.3 | 0.8 ± 0.3 | 0.7 ± 0.1 |
Serum albumin (g/dl) | 3.0 ± 0.9 | 3.0 ± 0.9 | 3.0 ± 0.9 |
Immunosuppressive therapy number (%) | |||
Prednisolone | 7 (41.2) | 4 (44.4) | 3 (37.5) |
Prednisolone + Cyclosporine | 2 (11.8) | 2 (22.2) | 0 |
Prednisolone + Tacrolimus | 1 (5.9) | 0 | 1 (12.5) |
Prednisolone + Mycophenolate mofetil | 1 (5.9) | 0 | 1 (12.5) |
Clinical course#1 | |||
6Â months | |||
 Proteinuria (g/day) | 1.7 ± 1.2 | 1.8 ± 1.2 | 1.5 ± 1.3 |
 Serum creatinine (mg/dl) | 0.9 ± 0.3 | 0.9 ± 0.3 | 0.8 ± 0.1 |
 Serum albumin (g/dl) | 3.4 ± 0.5 | 3.4 ± 0.5 | 3.5 ± 0.6 |
 % of complete remission (number) | 22.2 (2) | 16.7 (1) | 33.3 (1) |
 % of remission (number) | 66.7 (6) | 66.7 (4) | 66.7 (2) |
1Â year | |||
 Proteinuria (g/day) | 1.4 ± 1.7 | 1.7 ± 2.1 | 0.7 ± 0.8 |
 Serum creatinine (mg/dl) | 1.0 ± 0.4 | 1.1 ± 0.5 | 0.8 ± 0.3 |
 Serum albumin (g/dl) | 3.9 ± 0.4 | 3.9 ± 0.5 | 4.0 ± 0.2 |
 % of complete remission (number) | 44.4 (4) | 50.0 (3) | 33.3 (1) |
 % of remission (number) | 66.7 (6) | 66.7 (4) | 66.7 (2) |
