Figure 4
From: Loss of chaperone-mediated autophagy is associated with low vertebral cancellous bone mass
Skeletal analysis of young adult L2ACgKO mice. (a–h) Body weight measurements (a,e) and μCt analysis was performed on lumbar vertebrae 4 (L4) and femurs of 18-week-old female (a–d) and male (e–h) Lamp2AC global knock-out (L2ACgKO) mice and their wild-type (WT) littermates. (b,f) Cancellous bone mass and architecture were analyzed as bone volume over tissue volume (BV/TV), trabecular thickness (Tb.Th), trabecular spacing (Tb.Sp), trabecular number (Tb.N) in lumbar vertebrae 4. (d,h) Femoral cancellous bone mass and architecture were analyzed in the distal femur. (c,g) Femoral cortical thickness (Ct.Th) was measured at the midshaft. n = 8–10 mice/group. Bars indicate mean ± STDEV. p values were calculated and evaluated by Welch's t-test; *, p < 0.05.
