Figure 3 | Scientific Reports

Figure 3

From: GAIT-GM integrative cross-omics analyses reveal cholinergic defects in a C. elegans model of Parkinson’s disease

Figure 3

Correlation analysis between individual genes and metabolites points to potential cholinergic defects. (A) Output from the Gene/Metabolite Correlation Tool showing the 500 strongest correlations between individual genes and metabolites. Metabolites are represented in green, while genes are represented in blue. Red lines represent positive correlations and light blue lines signify negative correlations. (B) Gene Ontology analysis visualized by REVIGO for the largest cluster from (A) shows functional enrichment for neurotransmission, and in particular cholinergic synaptic transmission (red box). Gene lists were analyzed using gProfiler29 and visualized using REVIGO30.

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