Table 10 The non-compartmental PK parameters of TA after oral administration of 3 mg/kg (n = 10).
Parameter | Matrine | Oxymatrine | Sophocarpine | Sophoridine |
|---|---|---|---|---|
t1/2 (h) | 5.33 ± 0.87 | 3.82 ± 6.61 | 2.64 ± 1.15 | 6.02 ± 1.38 |
V (L/kg) | 0.05 ± 0.01 | 190.29 ± 259.77 | 0.29 ± 0.17 | 0.15 ± 0.03 |
CL (L/h/kg) | 0.01 ± 0.00 | 10.59 ± 8.13 | 0.07 ± 0.02 | 0.02 ± 0.00 |
AUC(0-t) (h/ng/mL) | 3797.53 ± 615.89 | 3.36 ± 1.69 | 348.96 ± 72.16 | 1312.38 ± 116.85 |
Cmax (ng/mL) | 381.20 ± 29.50 | 2.28 ± 1.02 | 42.19 ± 11.77 | 134.59 ± 20.39 |
Tmax (h) | 5.50 ± 2.60 | 1.39 ± 1.27 | 5.00 ± 3.20 | 6.00 ± 1.16 |
AUC(0-∞) (h/ng/mL) | 4069.04 ± 606.69 | 3.37 ± 1.69 | 352.08 ± 70.48 | 1442.56 ± 110.42 |
