Table 1 Number of carriers of P/LP germline variants according to age and living country region.
From: Detection of germline variants in Brazilian breast cancer patients using multigene panel testing
Patients with a positive finding: n (%) | |||||||||
|---|---|---|---|---|---|---|---|---|---|
Total cohort 1663 (100%) | BRCA1 97 (5.8%) | BRCA2 72 (4.3%) | BRCA1/2 167 (10.0%) | TP53 37 (2.2%) | TP53 R337H 26 (1.6%) | High-penetrant BC genes 223 (13.4%) | Moderate- penetrant BC genes 69 (4.1%) | Multigene panel 335 (20.1%) | |
Age at BC diagnosis or age at testing | |||||||||
≤ 35 years | 481 | 45 (9.3) | 22 (4.6) | 66 (13.7) | 16 (3.3) | 7 (1.4) | 86 (17.9) | 23 (4.8) | 124 (25.8) |
≤ 50 years | 1289 | 88 (6.8) | 57 (4.4) | 143 (11.1) | 33 (2.6) | 22 (1.7) | 192 (14.9) | 56 (4.3) | 286 (22.2) |
≤ 65 years | 1593 | 96 (6.0) | 69 (4.3) | 163 (10.2) | 37 (2.3) | 26 (1.6) | 219 (13.7) | 65 (4.1) | 326 (20.5) |
Mean, y (SD) | 42.9 (11.2) | 38 (9.2) | 42.1 (10.6) | 39.8 (10) | 39.2 (10.5) | 42.2 (10.9) | 39.9 (9.9) | 42.6 (12.1) | 40.6 (10.6) |
Median, y(min–max) | 41 (12–87) | 36 (23–66) | 40 (21–76) | 38 (21–76) | 38 (21–65) | 40.5 (23–65) | 39 (21–76) | 39 (24–87) | 39 (21–87) |
Regions of Brazil | |||||||||
Southeast | 863 | 54 (6.3) | 44 (5.1) | 96 (11.1) | 22 (2.5) | 15 (1.7) | 130 (15.1) | 37 (4.3) | 190 (22.0) |
South | 293 | 15 (5.1) | 12 (4.1) | 27 (9.2) | 10 (3.4) | 8 (2.7) | 40 (13.6) | 11 (3.7) | 60 (20.5) |
North | 26 | 0 (0.0) | 0 (0.0) | 0 (0.0) | 0 (0.0) | 0 (0.0) | 0 (0.0) | 3 (11.5) | 3 (11.5) |
Northeast | 283 | 9 (3.2) | 7 (2.5) | 16 (5.6) | 2 (0.7) | 1 (0.3) | 21 (7.4) | 11 (3.9) | 40 (14.1) |
Central-west | 198 | 19 (9.6) | 9 (4.5) | 28 (14.1) | 3 (1.5) | 2 (1.0) | 32 (16.2) | 7 (3.5) | 42 (21.2) |
