Table 2 Study characteristics for studies that were used in these meta-analyses including Participant numbers at baseline, adjuvant therapy type, type of exercise intervention used, intervention details, intervention duration, end follow up time point used, ages of participants in each study and which outcome measures the studies contributed to.
Study | Participant numbers at baseline | Adjuvant therapy type | Type of exercise intervention | Intervention details | Intervention Duration (Weeks) | End follow up timepoint used in analysis (Weeks) | Ages of participants (Years) | Outcomes reported in this meta-analysis |
|---|---|---|---|---|---|---|---|---|
Cornette et al.13 | Intervention (N = 20) Control (N = 22) | Chemotherapy (Neoadjuvant or adjuvant) followed by radiotherapy | Resistance and endurance | Randomized 27-week home-based exercise program combining strength and endurance training throughout adjuvant chemotherapy lasting up to 40 min per session, 3 times per week | 54 | 54 | 18–75 | Cardiorespiratory fitness (VO2peak), Depression, Global fatigue, Lower body muscular strength (1 RM leg) and Quality of Life (QOL) |
Dong et al.14 | Intervention (N = 30) Control (N = 30) | Chemotherapy/postoperative radiotherapy | Resistance and endurance | Randomized 12-week internet-based exercise intervention consisting of resistance and endurance training lasting 30 min per session, 3 times per week. Followed by 40 weeks of unsupervised exercise intervention | 12 | 52 | 43–59 | Cardiorespiratory fitness (VO2peak), Lower body muscular strength (chair stand test), Social Functioning |
Cornette et al.15 | Intervention (N = 22) Control (N = 22) | Adjuvant or neoadjuvant chemotherapy and radiotherapy | Resistance and endurance | Randomized 27-week home-based exercise program combining strength and endurance training throughout adjuvant chemotherapy and radiotherapy | 54 | 54 | 40–64 | Cardiorespiratory fitness (VO2peak) |
Travier et al.16 | Intervention (N = 102) Control (N = 102) | Chemotherapy | Resistance and endurance | Randomized 18-week exercise program consisting of 2 endurance and strength exercise sessions weekly lasting 60 min per session. Each session was supervised by a physiotherapist | 18 | 36 | 25–75 | Cardiorespiratory fitness (VO2peak), Depression, Global Fatigue, Lower body muscular strength (left knee flexor peak torque at 60 degrees/s (nm)), QOL |
Waart et al.17 | Intervention (N = 76) Control (N = 77) | Chemotherapy | Resistance and endurance | Randomized resistance and endurance exercise program (OnTrack) twice weekly lasting 50 min per session. Supervised by physical therapists | Until 3 weeks after the final chemotherapy cycle | 26 weeks after final cycle of chemotherapy | 41–59 | Cardiorespiratory fitness (Endurance time, minutes), Global fatigue and Lower body muscular strength (Knee extension Nm) |
Casla et al.18 | Intervention (N = 47) Control (N = 47) | Chemotherapy and radiotherapy | Resistance and endurance | Randomized resistance and endurance exercise program based on the ACSM guidelines twice weekly. Complemented with an educational program about nutrition and exercise guidelines | 12 | 26 weeks after program completion | 18 + | Cardiorespiratory fitness (VO2max), Lower body muscular strength (Maximal strength legs/Weight) and QOL (SF36 physical) |
Husebø et al.25 | Intervention (N = 33) Control (N = 34) | Chemotherapy | Resistance and endurance | Randomized home-based strength and aerobic training lasting at least 30 min per session, 3 times per week | 24 | 50 | 18–70 | Cancer related fatigue |
Schmidt et al.26 | Intervention (N = 15) Control (N = 18) | Chemotherapy and radiotherapy | Resistance and endurance | Randomized strength endurance training consisting of 20 repetitions at 50% 1RM lasting 1 h per session, once weekly | 26 | 26 | 18–70 | Global Fatigue and QOL |
Schmidt et al.22 | Intervention (N = 49) Control (N = 49) | Chemotherapy | Resistance | Randomized progressive machine-based resistance training lasting 60 min per session twice weekly. Supervised by experienced therapists | 12 | 13 | 18 + | Depression, Global fatigue and QOL |
Cešeiko et al.27 | Intervention (N = 27) Control (N = 28) | Chemotherapy or radiotherapy or hormone therapy | Resistance | Randomized maximal strength training twice weekly | 12 | 12 | 18–63 | Global Fatigue, QOL (Global health status) and social functioning |
Steindorf et al.23 | Intervention (N = 80) Control (N = 80) | Radiotherapy | Resistance | Randomized progressive machine-based resistance exercise 60 min per session twice weekly | 12 | 13 | 18 + | Global Fatigue, QOL and depression |
Cešeiko et al.29 | Intervention (N = 27) Control (N = 28) | Radiotherapy or chemotherapy | Resistance | Randomized resistance training through 90% of 1RM twice weekly | 12 | 12 | 18–63 | Lower body muscular endurance (Time to Exhaustion) and Lower body muscular strength (Leg press 1RM) |
Wiskemann et al.30 | Intervention (N = 80) Control (N = 80) | Radiotherapy | Resistance | Randomized machine-based progressive resistance exercise 3 sets of a 12-repetition maximum | 12 | 13 | 18 + | Lower body muscular strength (Knee flexion (60°)) |
Al-Majid et al.19 | Intervention (N = 7) Control (N = 7) | Chemotherapy | Endurance | Randomized progressive endurance program on treadmill lasting at least 20 min, 2–3 times weekly | 12 | 16 | 21 + | Cardiorespiratory fitness (VO2max), Cancer related fatigue, QOL (FACT-B total) |
Bolam et al.20 | Intervention (N = 74) Control (N = 60) | Chemotherapy | Resistance vs Usual care and Endurance vs Usual care | Randomized resistance training using both machines and free weights. Endurance training with moderate intensity continuous aerobic exercise. Both training groups lasted 60 min per session, twice weekly | 16 | 104 | 18–70 | Cardiorespiratory fitness (VO2peak), Global Fatigue, Lower body muscular strength (Isometric mid-thigh pull), QOL and social functioning |
Schmidt et al.28 | Intervention (N = 21) Control (N = 26) | Chemotherapy | Resistance vs Usual care and Endurance vs Usual care | Randomized resistance training using 20 repetitions of 50% 1RM on multiple machines. Endurance training using an indoor bike. Both sessions lasted 60 min taking place twice weekly | 12 | 24 | 41–66 | Global Fatigue, Lower body muscular endurance (W/KG/BW), Lower body muscular strength (Leg press), QOL and social functioning |
Courneya et al.24 | Intervention (N = 104) Control (N = 96) | Chemotherapy | Endurance and Resistance vs just endurance | Randomized combined dose of resistance and endurance exercise lasting 50- 60 min vs just 25–30 min of endurance exercise. Both done 3 times weekly | Doesn’t say | 3–4 weeks after chemotherapy finished | 18 + | Depression |
An et al.21 | Intervention (N = 104) Control (N = 96) | Chemotherapy | Endurance and Resistance vs just endurance | Randomized combined dose of resistance and endurance exercise lasting 50- 60 min vs just 25–30 min of endurance exercise. Both done 3 times weekly | 18 | 104 | ≥ 18 | Cardiorespiratory fitness (VO2peak), Fatigue, Lower body muscular endurance (repetitions), and Lower body muscular strength |
