Figure 4

Relative viabilities of AML12 cells (blue bars) and HepG2 cells (red bars) after exposure to IR794-COOH (A), IR794-Morph (B) and IR794-Morph-Mpip (C) at various concentrations (0‒20 μM) for 6 h. (D) IC50 values of IR794-Morph and IR794-Morph-Mpip treated with HepG2 for 6, 48 and 72 h. Relative viabilities of HepG2 cells treated with IR794-Morph (E) and IR794-Morph-Mpip (F) for 6 h (blue bars), 48 h (orange bars) and 72 h (green bars). Statistical analysis is based on Paired Student’s T-test analysis (*P < 0.05, **P < 0.01, ***P < 0.001) where (A–C) is the comparison between AML-2 and HepG2 at the same concentration; (E,F) is the comparison between the treatment and the control.