Figure 8
(a) Visualization of the complete tubulin protein in complex with TTL (purple) and RB3 (yellow); α tubulin (dark gray) and β tubulin (light gray) subunits were taken from PDB 5JT2. Additionally, PCH-1, VLB, and VNC (cyan) ligands docked at the vinblastine site of tubulin are marked with dashed lines; (b–d) Visualization of ligands at the docking site of PCH-1/VLB/VNC ligands, respectively, shown as licorice, where the carbon atoms are stained with cyan, oxygen with red, and nitrogen with blue. Tubulin β1 and α2 are displayed as light gray and dark gray bands, respectively. Our proposed receptor amino acids that may interact with the ligand are in the form of a stick and are labeled. The hydrogen bonds are underlined with black dashed lines.
