Table 3 In vitro growth inhibitory activity of pyrazoles and reference compounds presented as an IC50 ± SD (µM) value representing a concentration that inhibits 50% of cell growth.
Compound | A-549 | H226 | H460 | HEK293 |
|---|---|---|---|---|
PCH-1 | 4.32 ± 0.28 | 4.69 ± 0.43 | 8.40 ± 1.10 | 20.95 ± 2.34 |
PCH-2 | > 100 | 40.46 ± 3.52 | 43.84 ± 1.12 | > 100 |
PCH-3 | > 100 | 86.70 ± 0.92 | 24.53 ± 1.74 | > 100 |
PCH-4 | > 100 | 86.70 ± 4.70 | 63.43 ± 3.34 | > 100 |
PCH-5 | 60.89 ± 4.30 | 57.99 ± 2.56 | 38.84 ± 1.77 | 46.99 ± 3.18 |
PCH-6 | 21.46 ± 4.26 | 24.36 ± 2.13 | 18.12 ± 2.13 | 42.90 ± 1.23 |
PCH-7 | > 100 | 41.49 ± 1.12 | 30.16 ± 2.14 | > 100 |
PCH-8 | > 100 | 61.11 ± 3.12 | 30.16 ± 2.14 | > 100 |
PCH-9 | 79.46 ± 4.97 | 38.38 ± 3.53 | 43.77 ± 3.97 | 34.43 ± 2.01 |
Cisplatin | 29.01 ± 0.12 | 17.47 ± 2.12 | 21.49 ± 1.87 | 28.45 ± 1.97 |
5-FU | 8.12 ± 1.01 | 4.01 ± 0.76 | 4.08 ± 0.43 | 11.09 ± 1.53 |
Etoposide | 0.54 ± 0.21 | 1.03 ± 0.16 | 0.05 ± 0.01 | 1.91 ± 0.97 |
