Table 1 Characteristics of total participants during hyperthyroidism before treatments and early euthyroidism states.

From: Brown adipose tissues mediate the metabolism of branched chain amino acids during the transitioning from hyperthyroidism to euthyroidism (TRIBUTE)

 

Hyperthyroidism

Euthyroidism

P-values

BMI (kg/m2)

21.8 ± 0.9

23.1 ± 1.0

 < 0.001

Body weight (kg)

56.0 ± 2.5

59.0 ± 2.8

 < 0.001

Fat mass (kg)

19.7 ± 1.6

20.6 ± 1.6

0.02

Lean mass (kg)

33.8 ± 1.5

35.9 ± 1.8

 < 0.001

RMR (kcal/day)

1750.0 ± 85.2

1439.0 ± 62.8

 < 0.001

Fasting glucose (mmol/L)

4.4 ± 0.1

4.5 ± 0.1

0.84

Fasting insulin (µU/mL)

5.6 ± 0.7

6.0 ± 0.8

0.58

HOMA-IR

1.1 ± 0.1

1.2 ± 0.2

0.65

Total cholesterol (mmol/L)

4.5 ± 0.3

5.5 ± 0.3

 < 0.001

LDL (mmol/L)

2.5 ± 0.2

3.3 ± 0.2

 < 0.001

HDL (mmol/L)

1.4 ± 0.1

1.7 ± 0.1

 < 0.001

Triglyceride (mmol/L)

1.4 ± 0.2

1.2 ± 0.2

0.06

VAT (cm3)

22.0 ± 2.9

22.4 ± 2.9

0.66

FT3 (pmol/L)

11.5 ± 1.4

5.4 ± 0.3

 < 0.001

FT4 (pmol/L)

28.5 ± 3.2

12.1 ± 1.3

 < 0.001

PET SUVmax (g/mL)

1.7 ± 0.2

1.9 ± 0.2

0.52

PET SUVmean (g/mL)

0.9 ± 0.1

0.8 ± 0.1

0.93

MR sFF (%)

72.3 ± 1.4

76.8 ± 1.4

 < 0.001

  1. N = 22. Data presented as mean ± SEM. P values represents Student’s t-test between hyperthyroidism and early euthyroidism, phases. N = 21 for PET SUV, MR FF and VAT data. Statistically significant values are shown in bold. BMI, body mass index, was calculated as body weight (kg) divided by the square of height (m)
  2. RMR resting metabolic rate, HOMA-IR homeostasis model assessment of insulin resistance, was calculated as fasting glucose*fasting insulin divided by 22.5, LDL low-density lipoprotein, HDL high-density lipoprotein, VAT visceral adipose tissue, FT3 free triiodothyronine, FT4 free thyroxine, PET positron emission tomography, MR magnetic resonance, SUV standardized uptake value, sFF supraclavicular fat fraction.
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