Table 4 Comparison amino acids profile between hyperthyroid state and euthyroid state in BAT-positive and BAT-negative participants.

From: Brown adipose tissues mediate the metabolism of branched chain amino acids during the transitioning from hyperthyroidism to euthyroidism (TRIBUTE)

 

BAT-positive

BAT-negative

Hyperthyroid

Euthyroid

P-values

Hyperthyroid

Euthyroid

P-values

SUVmax (g/mL)

2.4 ± 0.3

2.1 ± 0.4

0.72

1.3 ± 0.1

1.8 ± 0.3

0.17

SUVmean (g/mL)

1.2 ± 0.1

0.9 ± 0.1

0.07

0.7 ± 0.1

0.8 ± 0.1

0.17

sFF (%)

68.1 ± 1.5

72.7 ± 1.1

0.01

74.9 ± 1.8

79.3 ± 1.9

 < 0.001

Alanine

285.7 ± 23.5

284.6. ± 24.4

0.93

323.9 ± 16.9

361.3 ± 16.0

0.04

Aspartic acid

19.0 ± 1.9

17.2 ± 1.7

0.46

23.5 ± 3.1

24.9 ± 2.3

0.69

Glutamic acid

100.7 ± 8.0

82.5 ± 10.0

0.07

114.6 ± 10.1

114.2 ± 10.6

0.97

Isoleucine

55.2 ± 3.7

44.5 ± 2.8

0.04

57.4 ± 4.5

56.5 ± 4.2

0.87

Leucine

114.6 ± 6.8

90.0 ± 4.9

0.006

118.6 ± 6.6

114.4 ± 6.7

0.57

Valine

246.8 ± 11.7

193.0 ± 11.6

0.004

239.5 ± 12.4

226.3 ± 13.2

0.34

Phenylalanine

63.3 ± 3.6

54.7 ± 2.0

0.03

66.2 ± 2.8

66.1 ± 2.5

0.99

Total AA

1714.0 ± 80.0

1557.0 ± 45.4

0.05

1804.0 ± 69.0

1836.7 ± 75.5

0.69

BCAA

416.6 ± 20.6

327.6 ± 18.2

0.005

415.5 ± 22.5

397.2 ± 23.6

0.46

  1. N = 21. BAT-positive n = 8, BAT-negative n = 13. Data presented as mean ± SEM. P values represents Independent Sample’s t-test between BAT-positive and BAT-negative subjects.
  2. Statistically significant values are shown in bold.
  3. SUVmax standardized uptake value maximum, SUVmean standardized uptake mean value, sFF supraclavicular fat fraction, AA amino acids, BCAA branched-chain amino acids (isoleucine, leucine and valine).
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