Table 5 Interaction effects between patient status (hyperthyroid and euthyroid states) and BAT status (BAT positive and BAT negative).

From: Brown adipose tissues mediate the metabolism of branched chain amino acids during the transitioning from hyperthyroidism to euthyroidism (TRIBUTE)

 

Hyperthyroid

Euthyroid

Patients status effects

BAT status effects

Interaction

BAT-positive

BAT-negative

BAT-positive

BAT-negative

P values

SUVmax (g/mL)

2.4 ± 0.3

1.3 ± 0.1

2.1 ± 0.4

1.8 ± 0.3

0.71

0.008

0.28

SUVmean (g/mL)

1.2 ± 0.1

0.7 ± 0.1

0.9 ± 0.1

0.8 ± 0.1

0.52

0.007

0.03

sFF (%)

68.1 ± 1.5

74.9 ± 1.8

72.7 ± 1.1

79.3 ± 1.9

 < 0.0001

0.01

0.90

Alanine

285.7 ± 23.5

323.9 ± 16.9

284.6 ± 24.4

361.3 ± 16.0

0.13

0.04

0.11

Aspartic acid

19.0 ± 1.9

23.5 ± 3.1

17.2 ± 1.7

24.9 ± 2.3

0.93

0.06

0.50

Glutamic acid

100.7 ± 8.0

114.6 ± 10.1

82.5 ± 10.0

114.2 ± 10.6

0.25

0.09

0.27

Isoleucine

55.2 ± 3.7

57.4 ± 4.5

44.5 ± 2.8

56.5 ± 4.2

0.13

0.17

0.19

Leucine

114.6 ± 6.8

118.6 ± 6.6

90.0 ± 4.9

114.4 ± 6.7

0.01

0.10

0.06

Valine

246.8 ± 11.7

239.5 ± 12.4

193.0 ± 11.6

226.3 ± 13.2

0.003

0.43

0.05

Phenylalanine

63.3 ± 3.6

66.2 ± 2.8

54.7 ± 2.0

66.1 ± 2.5

0.08

0.05

0.08

Total AA

1714.0 ± 80.0

1804.0 ± 69.0

1557.0 ± 45.4

1836.7 ± 75.5

0.30

0.05

0.12

BCAA

416.6 ± 20.6

415.5 ± 22.5

327.6 ± 18.2

397.2 ± 23.6

0.007

0.24

0.06

  1. N = 21. BAT-positive n = 8, BAT-negative n = 13. Data presented as mean ± SEM. The patients’ status effects, BAT status effects and interactions between patients’ status and BAT status were tested using linear mixed effects model adjusted by BMI.
  2. Statistically significant values are shown in bold.
  3. SUVmax standardized uptake value maximum, SUVmean standardized uptake mean value, sFF supraclavicular fat fraction, AA amino acids, BCAA branched-chain amino acids (isoleucine, leucine and valine).
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