Table 6 Correlations between BCAA concentration at hyperthyroid and euthyroid state with metabolic parameters at both state.

From: Brown adipose tissues mediate the metabolism of branched chain amino acids during the transitioning from hyperthyroidism to euthyroidism (TRIBUTE)

 

Hyperthyroid state

Euthyroid state

Valine

Leucine

Isoleucine

Valine

Leucine

Isoleucine

SUVmax (g/mL)

0.29 (0.20)

0.05 (0.85)

0.12 (0.62)

0.04 (0.87)

0.01 (0.96)

−0.13 (0.57)

SUVmean (g/mL)

0.27 (0.25)

0.18 (0.43)

0.11 (0.65)

0.25 (0.28)

0.25 (0.28)

0.04 (0.85)

sFF (%)

0.46 (0.04)

0.33 (0.14)

0.21 (0.16)

0.35 (0.12)

0.43 (0.05)

0.33 (0.15)

FT3 (mmol/L)

0.50 (0.02)

0.40 (0.07)

0.30 (0.17)

−0.10 (0.65)

−0.08 (0.72)

−0.20 (0.38)

RMR (kcal/day)

0.45 (0.03)

0.31 (0.17)

0.36 (0.10)

0.41 (0.06)

0.33 (0.13)

0.26 (0.23)

Insulin ( (µU/mL))

0.45 (0.04)

0.32 (0.15)

0.42 (0.05)

0.60 (0.003)

0.69 (0.001)

0.68 (0.001)

HOMA IR

0.48 (0.03)

0.29 (0.19)

0.40 (0.07)

0.62 (0.002)

0.69 (0.001)

0.69 (0.001)

VAT (cm3)

0.45 (0.04)

0.29 (0.19)

0.25 (0.26)

0.63 (0.002)

0.60 (0.004)

0.53 (0.01)

Fat mass (kg)

0.26 (0.25)

−0.01 (0.96)

0.01 (0.98)

0.51 (0.02)

0.41 (0.06)

0.47 (0.03)

Lean mass (kg)

0.33 (0.14)

0.27 (0.22)

0.41 (0.06)

0.60 (0.003)

0.60 (0.003)

0.46 (0.03)

Cholesterol (mmlo/L)

0.23 (0.31)

0.20 (0.38)

0.25 (0.27)

0.51 (0.02)

0.59 (0.004)

0.45 (0.04)

Triglyceride (mmol/L)

0.30 (0.17)

0.18 (0.42)

0.29 (0.19)

0.71 (< 0.001)

0.82 (< 0.001)

0.77 (< 0.001)

HDL (mmol/L)

−0.27 (0.22)

−0.19 (0.40)

−0.18 (0.43)

−0.31 (0.16)

v0.30 (0.18)

−0.29 (0.20)

  1. N = 22 except for SUV max, SUV mean, sFF and VAT data (N = 21). Correlations were used to assess relationship between variables. Valine, leucine and isoleucine at hyperthyroid state correlations with metabolic parameters at hyperthyroid state. Valine, leucine and isoleucine at euthyroid state correlations with metabolic parameters at euthyroid state. Significant correlations between variables are shown in bold with corresponding coefficient (r) and P values.
  2. SUVmax standardized uptake value maximum, SUVmean standardized uptake mean value, sFF supraclavicular fat fraction, FT3 free triiodothyronine, RMR resting metabolic rate, HOMA-IR homeostasis model assessment of insulin resistance, was calculated as fasting glucose*fasting insulin divided by 22.5, VAT visceral adipose tissue, HDL high-density lipoprotein.
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