Figure 4 | Scientific Reports

Figure 4

From: Computational identification of new potential transcriptional partners of ERRα in breast cancer cells: specific partners for specific targets

Figure 4

Transcriptional regulators associated with ESRRA in sPLS expression models of ERRα-activated genes. (a) Venn diagram of TRs with model coefficient > 0 and p-value < 0.05 identified from the ERRα-activated genes with reliable sPLS models in CCLE and GSE58135 datasets. The 24 selected TRs commonly identified in the two datasets are ordered according to the mean proportion of genes (mean gene prop, > 0.2) over the CCLE and the GSE58135 datasets for which the TR has positive coefficient in the 10 model replicates computed with one dataset. HAT: histone acetyltransferase, FACT: facilitates chromatin transcription, HMT: histone methyltransferase, chrom: chromatin, ACF: ATP-dependent chromatin assembly factor, TF: transcription factor. (b) Expression boxplots for the 24 selected TRs (same order as table above). Expression is upper-quartile normalized by sample and log2-transformed. (c) Genes including at least one of MYBBP1A, DDX21 or NFKB1 as selected TR in addition to ESRRA in their sPLS models.

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