Figure 4

IL-6 production in PVNS and RA synoviocyte supernatants 48 h after Cd exposure. Supernatants from PVNS and RA synoviocytes, used between passages 4 to 9, were collected 48 h after the treatment with increasing concentrations of Cd (0.01 ppm; 0.1 ppm; 1 ppm and 10 ppm; (A), n = 10 from 5 PVNS patients and 5 RA patients) or, in independent experiments, following a kinetic study (6 h, 24 h, 72 h and 6 days; (B); n = 3 from 3 PVNS patients and 3 RA patients). A quantification of IL-6 production was done by ELISA. Results are presented as mean ± SD, *p < 0.05.